Abstract： Objective： To observe the clinical effect of Tongbi Zhitong Tang for patients with residual pain after percutaneous transforaminal endoscopic discectomy(PTED) for lumbar disc herniation(LDH). Methods：A total of 150 cases of LDH patients with residual pain after PTED were selected as the study subjects and divided into two groups according to the treatment methods， with 75 cases in each group. After operation，the control group was treated with routine rehabilitation，and the observation group was treated with routine rehabilitation combined with Tongbi Zhitong Tang. The lumbar function， symptom scores and the expression levels of inflammatory factors in the two groups were compared. Results： Before treatment，there was no significant difference being found in the comparison of scores of Japanese Orthopaedic Association(JOA) and Oswestry Disability Index(ODI) between the two groups(P＞0.05). After treatment， the JOA scores in the two groups were increased(P＜0.05)， and the ODI scores were decreased(P＜0.05)；the JOA score in the observation group was higher than that in the control group，and the ODI score was lower(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of each symptom in Visual Analogue Scale(VAS) between the two groups(P＞0.05). After treatment，the scores of each symptom in VAS in the two groups were decreased(P＜0.05)，and the scores of each pain symptom in VAS in the observation group were lower than those in the control group(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of levels of malondialdehyde(MDA)，superoxide dismutase(SOD)，tumor necrosis factor- α(TNF- α) and interleukin- 6 (IL- 6) in serum between the two groups(P＞0.05). After treatment， the SOD levels in serum in the two groups were increased(P＜0.05)，and the levels of MDA，TNF-α and IL-6 were decreased(P＜0.05)；the SOD level in serum in the observation group was higher than that in the control group(P＜0.05)， and the levels of MDA， TNF- α and IL- 6 were lower(P＜0.05). Conclusion： Tongbi Zhitong Tang has a definite effect in treating patients with residual pain after PTED for LDH， which can effectively relieve pain， improve lumbar function and inhibit expressions of inflammatory factors.