Abstract： Objective： To observe the clinical effect of the therapy of Wenyang Huoxue Tongmai Prescription combined with Wentong Xiaozhong external application prescription on limb closed fracture. Methods： A total of 80 patients with limb closed fracture were divided into the control group and the treatment group according to the random number table method，with 40 cases in each group. The control group was treated with diclofenac sodium dual release enteric-coated capsules，and the treatment group was additionally treated with Wenyang Huoxue Tongmai Prescription combined with external application of Wentong Xiaozhong Prescription based on the treatment of the control group. Before and after treatment， the traditional Chinese medicine syndrome(TCM) scores， inflammatory mediators， hemorheology and growth factors indexes were compared between the two groups，and the clinical effects and safety in the two groups were evaluated. Results：The total effective rate was 92.50% in the treatment group，higher than that of 75.00% in the control group(P＜0.05). The clinical effect in the treatment group was better than that in the control group(P＜0.05). After treatment，the TCM syndrome scores，plasma viscosity and values of high-shear whole blood viscosity and low-shear whole blood viscosity in the two groups were decreased when compared with those before treatment， and the erythrocyte sedimentation rate(ESR) in the two groups were increased when compared with those before treatment(P＜0.05)，and the improvement in the above five indexes in the treatment group was better than that in the control group(P＜0.05). After treatment，the levels of serum soluble intercellular adhesion molecule- 1(sICAM- 1)，interleukin- 6(IL- 6)， bradykinin(BK) and prostaglandin E2(PGE2) in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of vascular endothelial growth factor(VEGF)， platelet- derived growth factor(PDGF)， fibroblast growth factor- 1(FGF- 1) and insulin- like growth factor- 1(IGF- 1) in the two groups were increased，and the improvement in the above eight indexes was better than that in the control group(P＜0.05). The clinical healing period of fracture in the treatment group was significantly shorter than that in the control group(P＜0.05)， and no serious adverse reactions occurred in both groups. Conclusion： The therapy of Wenyang Huoxue Tongmai Prescription combined with external application Wentong Xiaozhong Prescription has a definite curative effect on limb closed fracture，which can effectively improve the hemorheology and growth factors indexes，alleviate the inflammatory responses of patients， and accelerate the healing of fracture，with high safety.