Abstract： Objective： To observe the effect of warming- needle moxibustion on relieving knee joint pain and knee joint activity in patients with knee osteoarthritis. Methods：A total of 113 cases of patients with knee osteoarthritis were divided into the study group(57 cases) and the control group(56 cases) according to the odd-even number grouping method. The control group was treated with Voltalin，and the study group was treated with Voltalin and warming-needle and moxibustion. Clinical effects were compared between the two groups. Before and after treatment，the knee joint pain，knee joint activity，osteoarthritis indexes and bone metabolism indexes in the two groups before and after treatment were compared. Results：The total clinical effective rate was 94.74% in the study group，higher than that of 78.57% in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Visual Analogue Scale(VAS) scores and Lyshlom scores between the two groups(P＞0.05). After treatment， VAS scores in the two groups were decreased(P＜0.05)， and Lyshlom scores were increased(P＜0.05)；the VAS score in the study group was lower than that in the control group(P＜0.05)， and Lyshlom score was higher(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of Western Ontario and McMaster Universities Arthritis Index(WOMAC) between the two groups(P＞0.05). After treatment， each score of WOMAC in the two groups was decreased(P＜0.05)，and each score in the study group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of serum calcitonin(CT)， osteocalcin(BGP) and osteoprotegerin(OPG) between the two groups(P＞0.05). After treatment，levels of CT，BGP and OPG in the two groups were increased(P＜0.05)，and the levels in the study group were higher than those in the control group(P＜0.05). Conclusion： Warming- needle and moxibustion has a significant clinical effect in treating knee osteoarthritis，which can effectively relieve knee joint pain，improve knee joint activity and bone metabolism，and reduce the severity of knee osteoarthritis.