Abstract：Objective：To observe the clinical effect of the therapy of Puergin Injection combined with Epley manipulation on patients with benign paroxysmal positional vertigo of posterior semicircular canal (PCBPPV)， and to analyze its effect on scores of Dizziness Handicap Inventory (DHI). Methods： A total of 80 PC- BPPV patients were divided into the control group and the study group according to the random number table method， with 40 cases in each group. The control group was treated with Epley manipulation， and the study group was additionally treated with Puerarin Injection on this basis. Both groups were treated for two weeks. The clinical effects， Chinese medicine syndrome scores and DHI scores before and after treatment were compared between the two groups， and the two groups were followed up for six months，and the recurrence of PC- BPPV was compared. Results：The total effective rate was 92.50% in the study group， higher than that of 72.50% in the control group(P＜0.05). Before treatment， there was no significant difference in the comparison of Chinese medicine syndrome scores between the two groups (P＞0.05). After one week and two weeks of treatment， the Chinese medicine syndrome scores in the two groups were gradually decreased(P＜0.05)，and the scores in the study group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of DHI score between the two groups(P＞0.05). After one week and two weeks of treatment， the DHI scores in the two groups were gradually decreased(P＜0.05)， and the score in the study group was lower than that in the control group(P＜0.05). Within six months after treatment， the recurrence rate was 2.50% in the study group， lower than that of 17.50% in the control group(P＜0.05). Conclusion： The therapy of Puerarin Injection combined with Epley manipulation has a significant therapeutic effect on the treatment of PC-BPPV，which can effectively improve the disease symptoms and reduce the recurrence rate of the disease，and it can be used as an effective auxiliary method for clinical treatment of PC-BPPV.