Abstract：To introduce Prof. YANG Ruyi's clinical experience in treating insomnia. Prof. YANG believes that insomnia can be diagnosed and treated from qi and blood，phlegm pathogen，emotion，and yin and yang of zang- fu organs. The etiology and pathogenesis of insomnia include qi and blood insufficiency leading to undernourishment of zang-fu organs，phlegm pathogen accumulation and stagnation resulting in disharmony of zang- fu organs， counterflow and disorder of the seven emotions making constraint and stagnation of the qi mechanism，and yin deficiency resulting in vigorous fire and yang disease not entering yin. In the treatment， methods are boosting qi and nourishing blood， dispelling phlegm and resolving stagnation， regulating qi and calming the mind， and enriching yin and subduing fire. Prescriptions are mainly Guipi Tang， Wendan Tang， Chaihu Shugan Powder， and Tianwang Buxin Pellets， and they are modified according to different syndromes，or combined with other prescriptions.