Objective： To discuss the mechanism of Daxianxiong Decoction in the treatment of acute diffuse peritonitis caused by gastrointestinal perforation based on network pharmacology. Methods： The Traditional Chinese Medicine Systems Pharmacology(TCMSP) database and analysis platform， chemistry database， and Encyclopedia of Traditional Chinese Medicine(ETCM) database were used to obtain and screen out the main chemical components and their corresponding targets of Rhei Radix et Rhizoma，Natrii Sulfas and Kansui Radix. Main disease targets were retrieved by databases including GeneCards， Online Mendelian Inheritance in Man(OMIM)， DisGeNet， and DrugBank. STRING platform was used to analyze protein interaction，construct protein- protein interaction(PPI) network and mine potential protein function modules in the network. Metascape platform was applied in the analysis of the “medicine- componenttarget” network and the biological processes and pathways it involved，the “component-disease targetpathway” network was drawn by Cytoscape 3.7.1 software， and molecular docking was verified by AutoDock Tools 1.5.6. Results： The core active components of Daxianxiong Decoction in treating acute diffuse diffuse peritonitis caused by gastrointestinal perforation were kaempferol，aloe-emodin，piceatannol， and kansuinin，horin A. The core targets were phosphatidylinositol-3-kinase(PIK3CA)，phosphatidylinositol 3- kinase regulatory subunit alpha(PIK3R1)， serine/threonine protein kinase 1(AKT1)， estrogen receptor (ESR1)，tumor protein P53(TP53)，etc. The biological pathway of Daxianxiong Decoction in the treatment of acute diffuse peritonitis caused by gastrointestinal perforation mainly acted on the phosphatidylinositol 3 kinase- protein kinase B(PI3K- Akt) signaling pathway， epidermal growth factor receptor- tyrosine kinase inhibitor(EGFR-TKI) medicine resistance pathway，and advanced glycation end products and AGE receptor (AGE-RAGE) signaling pathway of diabetic complications. Its major functions were involving in inflammatory responses and regulating cellular homeostasis and proliferation， and it also plays an important role in stimulating cell growth and inhibiting cell apoptosis. The results of molecular docking showed that kaempferol，aloe- emodin，and piceatannol were the core compounds of Daxianxiong Decoction，which had strong binding activities with the main targets of AKT1， ESR1， and TP53. Conclusion： Daxianxiong Decoction can treat acute diffuse peritonitis caused by gastrointestinal perforation by regulating the targets， including PIK3CA， PIK3R1 and AKT1， and its mechanism is closely related to the PI3K- Akt signaling pathway， EGFR- TKI medicine resistance pathway， and AGE- RAGE signaling pathway of diabetic complications.