Abstract： Objective： To observe the clinical effect of modified Jinsu Pellets combined with acupuncture and moxibustion for febrile convulsion in children and its effect on levels of serum high mobility group protein box 1(HMGB1)， interleukin-6(IL-6) and serum ferritin(SF). Methods： A total of 100 cases of children with febrile convulsion were selected and serum divided into the control group and the observation group according to different treatment methods， with 50 cases in each group. The control group was treated with routine therapy of modern medicine as well as acupuncture and moxibustion，and the observation group was additionally treated with modified Jinsu pellets based on the treatment of the control group. The clinical effects were compared between the two groups； the disappearance time of convulsion，the recovery time of consciousness and the antipyretic time in the two groups were observed. Before and after treatment，the changes in the levels of nerve factors including neuron- specific enolase (NSE)， brain- derived neurotrophic factor(BNDF) and neuropeptide- Y(NPY)， SF， IL- 6， HMGB1， and serum immunoglobulin lgG，lgM and lgA in the two groups were compared. Results：The total effective rate was 90% in the observation group and 72% in the control group，the difference being significant(P＜ 0.05). The antipyretic time，the recovery time of consciousness and the disappearance time of convulsion in the observation group were shorter than those in the control group，the difference being significant(P＜ 0.05). After treatment， the levels of NSE， NPY and BDNF in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of NSE，NPY and BDNF in the observation group were lower than those in the control group(P＜0.05). After treatment，the SF levels in the two groups were increased when compared with those before treatment，and the levels of HMGB1 and IL-6 were decreased，the difference being significant(P＜0.05). After treatment，the SF level in the observation group was higher and the levels of HMGB1 and IL-6 were lower than that in the control group，the difference being significant(P＜0.05). After treatment， the levels of lgG， lgM and lgA in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three levels in the observation group were lower than those in the control group(P＜0.05). The recurrence rate was 4% in the observation group and 26% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of modified Jinsu Pellets combined with acupuncture and moxibustion for febrile convulsion in children has a significant clinical effect， which can effectively reduce the inflammatory responses and improve the levels of immunoglobulin.