Abstract： Objective： To observe the curative effect of Qingre Qupao Decoction combined with Valacyclovir for senile herpes zoster in acute stage. Methods： A total of 80 cases of senile patients with herpes zoster in acute stage were randomly divided into the control group and the study group ， with 40 cases in each group. The control group was treated with Valacyclovir，and the study group was treated with Qingre Qupao Decoction combined with Valacyclovir. The curative effects in the two groups were compared. Results：The time of controlling herpes，incrustation，decrustation and analgesia in the study group was shorter than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the scores of Visual Analogue Scale(VAS) and Quality of Sleep(QS) between the two groups(P＞0.05). After treatment， VAS scores in the two groups were decreased(P＜0.05) and QS scores were increased(P＜0.05); the VAS score in the study group was lower than that in the control group(P＜0.05)，and the QS score was higher(P＜0.05). The cure rate was 85.00% in the study group，higher than that of 45.00% in the control group. The total effective rate was 100% in the study group，higher than that of 80.00% in the control group. Conclusion：The therapy of Qingre Qupao Decoction combined with Valacyclovir has a significant effect in the treatment of senile herpes zoster in acute stage， which can relieve pain， greatly shorten the treatment time， improve the sleep quality and enhance the curative effect on the whole，with good safety.