Abstract：Objective：To observe the clinical effect of Jieyu Baihe Formula combined with five-phase music therapy for emotional disorder in perimenopausal syndrome(PPS). Methods：A total of 98 cases of PPS patients with emotional disorder were divided into the observation group and the control group according to the random number table method，with 49 cases in each group. The control group was given oral administration of Femoston， and the observation group was additionally treated with Jieyu Baihe Formula combined with five-phase music therapy based on the treatment of the control group. The clinical effects in the two groups were compared. Before and after treatment，the changes in Hamilton Anxiety Scale(HAMA)， Hamilton Depression Scale(HAMD- 17)， Modified Kupperman Scale， Pittsburgh Sleep Quality Index(PSQI)， and levels of sex hormones including estrogen(E2) and follicle stimulating hormone (FSH) in serum were compared between the two groups. Results：The clinical effect in the observation group was better than that in the control group(P＜0.05). After treatment，the scores of HAMA，HAMD-17， Modified Kupperman Scale and PSQI in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above four scores in the observation group were lower than those in the control group(P＜0.05). After treatment，the E2 levels in the two groups were increased when compared with those before treatment(P＜0.05)，and the FSH levels were decreased，differences being significant (P＜0.05)； the E2 level in the observation group was higher， and FSH level was lower than that in the control group， differences being significant(P＜0.05). During treatment， there was no serious adverse reaction of drug in the two groups. Conclusion： Jieyu Baihe Formula combined with five- phase music therapy has a good clinical effect in treating emotional disorder in PPS，and is helpful to relieve symptoms including anxiety and depression，and improve levels of sex hormones and quality of life.