Abstract： Objective： To observe the clinical effect of Shenqi Jiangtang Granules on type 2 diabetic peripheral neuropathy(DPN). Methods： A total of 90 cases of DPN were selected and divided into the control group and the observation group according to the random number table method，with 45 cases in each group. Based on routine western medicine， the control group was additionally given Thioctic Acid Injection，and the observation group was additionally treated with Shenqi Jiangtang Granules based on the treatment of the control group. The two groups were treated continually for four weeks. The clinical effects，hemoglobin A1c(HbA1c)，fasting blood glucose(FBG)，and postprandial two- hour blood glucose (P2hBG)， as well as the motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity (SNCV) of tibial nerve and nervus peroneus communis in the two groups were compared. Results：The total effective rate was 93.33% in the observation group，significantly higher than that of 75.56% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of FBG， P2hBG and HbA1c between the two groups(P＞0.05)； after treatment，the above three levels in both groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above three levels in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of MNCV and SNCV of tibial nerve and nervus peroneus communis(P＞0.05)； after treatment， the MNCV and SNCV of tibial nerve and nervus peroneus communis in both groups were significantly increased when compared with those before treatment(P＜0.05)， and the improvement in above indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion：Shenqi Jiangtang Granules as the adjuvant treatment for type 2 DPN can further improve the level of blood glucose and peripheral neuropathy of patients and enhance the clinical effect.