Abstract： This paper introduces the clinical experience of Professor ZHENG Yanlin in treating central serous chorioretinopathy from syndrome differentiation and treatment of depression. Professor ZHENG holds that central serous chorioretinopathy is caused by the dysfunction of the liver， spleen and other viscera， the abnormal movement of qi， blood， fluid， essence and spirit， the collateral depression and water retention， the water- dampness retention， and the depression in retina and macula lutea. The disease location lies in the water orbiculus，retina，and macula lutea，which is closely related to the liver， spleen and kidney. Dampness depression in macula lutea is the basic pathogenesis， and dampness depression exists through the whole process of the disease. Therefore，the basic treatment method is to resolve depression and stagnation， and to unblock collaterals and eliminate dampness， and based on which the syndrome differentiation and treatment is carried out，and various methods are flexibly applied， including smoothing the liver and fortifying the spleen， unblocking collaterals and eliminating dampness， draining dampness and clearing heat or clearing heat and resolving phlegm，warming yang and promoting urination，and enriching yin and promoting urination.