Abstract： Objective： To analyze the molecular mechanism of Fritillariae Cirrhosae Bulbus in treating pneumonia by applying methods of network pharmacology and molecular docking， so as to provide theoretical basis for subsequent research. Methods： The effective ingredients of Fritillariae Cirrhosae Bulbus were screened according to the published literature，database and ADEM parameters；the targets of all the effective ingredients of Fritillariae Cirrhosae Bulbus were found on the SwissTargetPrediction， Similarity ensemble approach and other databases；the therapeutic targets of pneumonia were searched in the DisgeNet，GeneCards and other databases；the intersections of the targets through the Venn diagram were the treatment targets of Fritillariae Cirrhosae Bulbus for pneumonia；the PPI network of the treatment targets was built through the String database； the top five targets of comprehensive concentration were screened out by using Cypnas in Cytoscape 3.8.0，serving as the core targets of Fritillariae Cirrhosae Bulbus for the treatment of pneumonia； the target gene GO enrichment and KEGG pathway enrichment were carried out on the Metascape website； the network diagram of targets of effective ingredients and treatment for pneumonia were constructed by using Cytoscape 3.8.0； the selected effective ingredients and core targets were given molecular docking by using Cdocker in Discovery Studio 2019. Results：A total of 59 effective ingredients were screened， including 22 alkaloids， 20 organic acids， 8 nucleosides and 9 other substances. A total of 100 targets of Fritillariae Cirrhosae Bulbus for the treatment of pneumonia were screened out by Venn diagram. After concentrated screening，5 core targets of Fritillariae Cirrhosae Bulbus for the treatment of pneumonia were selected as STAT3， AKT1， SRC， MAPK3 and EGFR respectively. The analysis of GO enrichment and KEGG pathway enrichment found that the molecular functions of the targets of Fritillariae Cirrhosae Bulbus for pneumonia were enriched in serine- type peptidase activity，protein tyrosine kinase activity of transmembrane receptors，kinase binding，etc；the biological processes were enriched in leukocyte migration，regulation of cell- cell adhesion，regulation of defense response，etc；the cell constituents were enriched in the membrane raft，the lateral part of the plasma membrane and the cyst cavity，etc；the KEGG pathway was enriched in the AGE-RAGE signaling pathway and hepatitis B signaling pathway of cancer pathway and diabetes complications； the biological processes in which core targets were involved included cytokine signaling pathway and positive regulation process of protein， and KEGG pathway included the role of AGE- RAGE signaling pathway in diabetes complications，and hepatitis B，and chemokine signaling pathway，etc；molecular docking showed that the alkaloid components of Fritillariae Cirrhosae Bulbus could dock with STAT3 and AKT1，and the organic acid ingredients could dock with EGFR. Conclusion：Fritillariae Cirrhosae Bulbus treats pneumonia through multiple targets，multiple pathways and multiple approaches，and the active ingredients have good druglike properties.