Abstract： Objective： To observe the clinical effect of the therapy of Qiangli Dingxuan Tablets combined with Alprostadil on vertigo symptom due to insufficiency of cerebral blood supply and its effect on hemodynamics. Methods： A total of 198 patients with vertigo symptom due to insufficiency of cerebral blood supply were selected as research objects and divided into the control group and the observation group according to the random number table method，with 99 cases in each group. The control group was given Alprostadil Injection，and the observation group was additionally treated with oral use of Qiangli Dingxuan Tablets on the basis of the treatment of the control group. Both groups were treated for 2 weeks. The clinical effects and adverse reactions in the two groups were compared. Before and after treatment， the changes in the traditional Chinese medicine (TCM) syndrome scores， hemodynamic indexes， scores of Evaluation Scale for Cervical Vertigo (ESCV) and functional scale for cervical spondylosis of vertebral artery type (FS-CSA) were also compared in the two groups. Results：The total effective rate was 90.91% in the observation group，which was higher than that of 80.81% in the control group (P＜0.05). After treatment， the TCM syndrome scores in both groups were decreased when compared with those before treatment (P＜ 0.05)；the TCM syndrome scores in the observation group were lower than those in the control group (P＜ 0.05). After treatment，the ESCV scores in the two groups were higher than those before treatment，and the FS-CSA scores in the two groups were lower than those before treatment (P＜0.05)；the ESCV score in the observation group was higher than that in the control group，and the FS-CSA score was lower than that in the control group (P＜0.05). After treatment，the levels of mean velocity (Vm) of the vertebral artery and the basilar artery in both groups were increased when compared with those before treatment，and the levels of pulse index (PI) were decreased (P＜0.05)； the levels of Vm of the vertebral artery and basilar artery in the observation groups were higher than those in the control group，and the PI was lower than that in the control group (P＜0.05). Conclusion： The therapy of Qiangli Dingxuan Tablets combined with Alprostadil can relieve the clinical symptoms in patients with vertigo symptom due to insufficiency of cerebral blood supply，improve the quality of life，and regulate the hemodynamic indexes.