Abstract： Objective： To observe the clinical effect of the method of supplementing the spleen， harmonizing the stomach，and directing the turbid downward for chronic kidney disease in early and middle stages with spleen deficiency and excessive dampness syndrome. Methods：A total of 94 cases of patients with chronic kidney disease in the early and middle stages were divided into the control group and the observation group according to the random number table method，with 47 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with the method of supplementing the spleen， harmonizing the stomach， and directing the turbid downward based on the treatment of the control group. Clinical effects were evaluated in the two groups. The changes in traditional Chinese medicine (TCM) syndrome scores，kidney function，and renal blood flow，as well as the levels of inflammatory factors， and the immune function before and after treatment were compared between the two groups. Results：The total effective rate was 89.36% in the observation group，higher than that of 72.34% in the control group (P＜0.05). After treatment，each TCM syndrome score in the two groups was lower than that before treatment (P＜0.05)，and each TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment，levels of serum creatinine (SCr)， blood urea nitrogen (BUN)， cystatin- C (Cys- C) β2- microglobulin (β2- MG)， interleukin- 6 (IL- 6)， Creactive protein (CRP) and immunoglobulin antibody G (IgG) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the observation group were lower than those in the control group (P＜0.05)；estimated glomerular filtration rates (eGFR) and complement C3 levels in the two groups were increased when compared with those before treatment， and eGFR and complement C3 levels in the observation group were higher than those in the control group (P＜0.05). After treatment，mean flow intensity (Imix) and mean blood flow velocity (Vmix) in the observation were higher than those before treatment and those in the control group (P＜0.05). Conclusion：For patients with chronic kidney disease in early and middle stages with spleen deficiency and excessive dampness syndrome，the method of supplementing the spleen， harmonizing the stomach， and directing the turbid downward can effectively improve the kidney function， renal cortex blood flow， the degree of renal inflammation， and the immune function，with a definite curative effect.