Abstract：Objective：To observe the clinical effect of the therapy of Yiqi Huoxue Tongmai Decoction combined with Chinese massage on closed Pilon fracture. Methods： A total of 190 patients with closed pilon fracture were selected and divided into the control group and the observation group according to random number table method，with 95 patients in each group. The control group was given 20% Mannitol Injection by intravenous drip， and the observation group was given the therapy of Yiqi Huoxue Tongmai Decoction combined with Chinese massage. The therapeutic effect on swelling and the fracture healing were compared between the two groups. Results：The total effective rate was 87.37% in the observation group， higher than that of 73.68% in the control group (P＜0.05). The change time of calf circumference diameter and the time from admission to surgery in the observation group were significantly shorter than those in the control group (P＜0.05). The time of soft tissue repair，swelling elimination and fracture healing in the observation group was respectively shorter than that in the control group (P＜0.05). The pain scores in the observation group before surgery，one day after surgery and 7 days after surgery were lower than those in the control group (P＜0.05). The CT value in the observation group was higher than that in the control group at the third month and sixth month of follow-up after the surgery (P＜0.05). Conclusion：The therapy of Yiqi Huoxue Tongmai Decoction combined with Chinese massage can significantly relieve the early limb swelling of patients with closed Pilon fracture，eliminate the swelling in a shorter time，effectively reduce the pain of affected limbs，shorten the preparation time for surgery，and create favorable conditions for the prognosis.