Abstract： Objective： To observe the clinical effect of Kuntai Capsules combined with Femoston for menopause syndrome (CS). Methods： A total of 90 cases of CS patients were randomly divided into the routine group and the study group， with 45 cases in each group. The routine group was treated with Femoston，and the study group was treated with Femoston combined with Kuntai Capsules. Sex hormone levels，modified Kupperman scores and sleep status before and after treatment as well as clinical effects after treatment were compared between the two groups. Results： Before treatment， there was no significant difference being found in the comparison of the levels of follicle- stimulating hormones (FSH)， estradiol (E2) and luteinizing hormone (LH) between the two groups (P＞0.05)；after treatment，the levels of FSH and LH in the two groups were decreased (P＜0.05)，and the levels of E2 were increased (P＜0.05)； the levels of FSH and LH in the study group were lower than those in the routine group (P＜0.05)，and the level of E2 was higher than that in the routine group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of sleep time and time for falling asleep between the two groups (P＞0.05)；after treatment，the sleep time in the two groups was prolonged and the time for falling asleep was shortened (P＜0.05)；the sleep time in the study group was longer than that in the routine group (P＜ 0.05)， and the time for falling asleep was shorter than that in the routine group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of modified Kupperman scores between the two groups (P＞0.05)；after treatment，modified Kupperman scores in the two groups were decreased (P＜0.05)，and the score in the study group was lower than that in the routine group (P＜ 0.05). After treatment，the total effective rate was 88.89% in the study group，higher than that of 71.11% in the routine group (P＜0.05). During the treatment，there were no obvious adverse reactions in the two groups. Conclusion：Kuntai Capsules combined with Femoston for CS in female can regulate the secretion of sex hormones and improve the clinical symptoms of patients，with a safe and reliable curative effect.