Abstract： Objective： To study the administration rule of Chinese medicine in treating post- stroke spasticity (PSS) based on data mining technology. Methods： The clinical research literatures on the treatment of PSS by internal administration of Chinese medicine decoction were retrieved from Chinese and English databases， including China National Knowledge Infrastructure (CNKI)， VIP Database， Wanfang Database， Chinese Biomedical Literature Database (CBM)， PubMed， EmBase， Cochrane Library and Web of Science， with a publishing date from the establishment day to May 8， 2022. The data mining technology was used to analyze the frequency， nature， flavour， channel entry， curative effect， association rule， complex network and systematic cluster. Results： A total of 195 literatures were included， including 166 Chinese herbs. The medicinal nature of the herbs was mainly warm and cold，and the medicinal flavor was mostly sweet，bitter and pungent. The common channel entries were to the liver， spleen and heart， and the main curative effects were to supplement and boost， invigorate blood and dissolve stasis，remove wind-damp，and calm the liver and extinguish wind. The top five Chinese herbs in frequency were Paeoniae Radix Alba， Angelicae Sinensis Radix， Chuanxiong Rhizoma， Pheretima and Astragali Radix. Fifteen core herbal combinations were obtained，among which the herbal pair with the highest degree of support was Angelicae Sinensis Radix- Astragali Radix (deficiency supplementing herb- deficiency supplementing herb)， and the herbal pair with the highest degree of confidence was Carthami Flos- Persicae Semen (blood invigorating and stasis dissolving herb-blood invigorating and stasis dissolving herb). Four kinds of formulas were obtained， which were modified by Guizhi Decoction， Tianma Gouteng Decoction， Daqinjiao Decoction and Buyang Huanwu Decoction. Conclusion： In the treatment of PSS， Chinese medicine mainly emphasizes boosting qi， enriching yin and softening tendons， and also adopts the methods of invigorating blood and dissolving stasis，extinguishing wind and arresting convulsion，and dispelling wind and unblocking the collaterals，and pays attention to treating the symptom and root cause simultaneously and treating based on syndrome differentiation.