Abstract： Objective： To observe the clinical effect of Shenjiao Decoction combined with Oryzanol Tablets for neurasthenia. Methods：A total of 60 cases of patients with neurasthenia were divided into the treatment group and the control group according to the random number table method， with 30 cases in each group. The control group was treated with Oryzanol Tablets； the treatment group was treated with Oryzanol Tablets combined with Shenjiao Decoction. After 12 weeks of continuous treatment，the changes in scores of Hamilton Depression Scale (HAMD- 17)， Symptom Checklist- 90 (SCL- 90) and Pittsburgh Sleep Quality Index (PSQI) before and after treatment as well as the total clinical effects in the two groups were compared. Results：The total effective rate was 96.67% in the treatment group，significantly higher than that of 73.33% in the control group， the difference between the two groups being significant (P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of the scores of HAMD-17 and SCL-90 between the two groups (P＞0.05). After treatment，the scores of HAMD-17 and SCL-90 in the two groups were significantly decreased when compared with those before treatment (P＜ 0.05)，and the above 2 scores in the treatment group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of sleep quality， time for falling asleep， sleep efficiency， sleep time， sleep disorder， daytime function and hypnotic drugs in PSQI scale and the total scores between the two groups (P＞0.05). After treatment，each score in PSQI scale and the total scores in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the above scores in the treatment group were lower than those in the control group (P＜0.05). Conclusion： Shenjiao Decoction combined with Oryzanol Tablets has a significant clinical effect in the treatment of neurasthenia， which can effectively improve depression and psychological state of patients，and reduce sleep disorders.