Abstract：Objective：To observe the clinical effect of Guanxin Danshen Dripping Pills combined with western medicine on initial angina of coronary heart disease with qi stagnation and blood stasis syndrome. Methods： A total of 120 cases with initial angina of coronary heart disease with qi stagnation and blood stasis syndrome were selected and divided into the control group and the treatment group according to the random number table method，with 60 cases in each group. The control group was treated with Isosorbide Mononitrate Tablets and Aspirin Tablets，treat with Nitroglycerin Tablets in case of coronary heart disease， and the treatment group was additionally given Guanxin Danshen Dripping Pills based on the treatment of the control group. The two groups were treated for 8 weeks. The clinical effects in both groups were compared. Before and after treatment， the changes of traditional Chinese medicine(TCM) syndrome scores，levels of serum P- selectin (Ps) and endothelin- 1 (ET- 1) in serum，as well as the heart function indexes[the cardiac output (CO)， left ventricular end diastolic diameter (LVEDD)， left ventricular ejection fraction (LVEF)， cardiac index (CI)] in both groups were observed. Results： After treatment， The total effective rate was 96.67% in the treatment group， higher than that of 85.00% in the control group (P＜ 0.05). The scores of chest pain，chest distress，hypochondrium and palpitation and fullness in chest as well as the total score in both groups were decreased when compared with those before treatment (P＜0.05)， and the four scores above as well as the total score in the treatment group were lower than those in the control group (P＜0.05). Compared with those before treatment，the levels of Ps and ET-1 in serum in the two groups were decreased (P＜0.05)，and the two levels above in the treatment group were lower than those in the control group (P＜0.05). The CO，LVEF and CI in both groups were increased when compared with those before treatment (P＜0.05)，and the CO，LVEF and CI in the treatment group were higher than those in the control group (P＜0.05)； LVEDD in both groups were reduced when compared with those before treatment (P＜0.05)， and the LVEDD in the treatment group was shorter than that in the control group (P＜0.05). Conclusion： The therapy of Guanxin Danshen Dripping Pills combined with western medicine has a significant clinical effect on initial angina of coronary heart disease with qi stagnation and blood stasis syndrome， which can well mitigate the clinical symptomes of patients， decrease the concentration of serum Ps and ET-1，and improve the heart function.