Abstract： Objective： To observe the clinical effect of Wuzhi Capsules for liver fibrosis induced by chronic hepatitis B and its effect on levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in serum. Methods：A total of 78 cases of patients with liver fibrosis induced by chronic hepatitis B were selected and divided into the treatment group and the control group according to the random number table method，with 39 cases in each group. The control group was treated with Entecavir Dispersible Tablets， and the treatment group was additionally treated with Wuzhi Capsules based on the treatment of the control group. Both groups were treated for 24 weeks. The clinical effects as well as the changes in levels of liver fibrosis indexes including hyaluronic acid (HA)，type Ⅲ procollagen (PCⅢ)，type Ⅳ collagen (Ⅳ-C) and laminin (LN) in serum and inflammatory factors including TNF- α and IL- 6 were compared between the two groups. Results： The total effective rate was 92.31% in the treatment group， significantly higher than that of 71.79% in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of HA，PCⅢ，Ⅳ-C and LN between the two groups (P＞0.05). After treatment， the levels of HA， PC Ⅲ， Ⅳ- C and LN in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the above indexes in the treatment group were significantly lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of TNF-α and IL-6 between the two groups (P＞0.05)； After treatment， the levels of TNF- α and IL- 6 in the two groups were significantly decreased when compared with those before treatment (P＜0.05)， and the levels of TNF- α and IL- 6 in the treatment group were significantly lower than those in the control group (P＜0.05). Conclusion：The therapy of Wuzhi Capsules combined with Entecavir Dispersible Tablets for patients with liver fibrosis induced by chronic hepatitis B can significantly improve the serological indexes of liver fibrosis and reduce the levels of inflammatory factors，with a significant clinical effect.