Abstract：Objective：To observe the clinical effect of Fengliao Changweikang Granules combined with Pivecuronium Bromide Tablets for diarrhea- type irritable bowel syndrome (D- IBS) with spleen- stomach damp-heat syndrome. Methods：A total of 104 D-IBS patients with spleen-stomach damp-heat syndrome were divided into the treatment group and the control group by the random number table method， with 52 cases in each group. The control group was treated with Pivecuronium Bromide Tablets ， and the treatment group was additionally treated with Fengliao Changweikang Granules based on the treatment of the control group. Both groups were treated for 8 weeks. The clinical effects， incidence of adverse reactions during the treatment，as well as the traditional Chinese medicine (TCM) syndrome scores and the levels of inflammatory factors in serum，including tumor necrosis factor- α (TNF-α)，interleukin- 6 (IL-6) and interleukin- 17 (IL- 17) before and after treatment in the two groups were compared. Results： After treatment，the total clinical effective rate was 98.08% in the treatment group，higher than that of 82.69% in the control group (P＜0.05). The scores of abdominal pain， ungratifying or urgent diarrhea， distension and distress of stomach duct，and fetid mouth odor and bitter taste in the mouth as well as the total scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the above four scores as well as the total score in the treatment group were lower than those in the control group (P＜ 0.05). Compared with those before treatment，the levels of serum TNF-α，IL-6 and IL-17 in both groups were decreased (P＜0.05)，and the three levels above in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions in the two groups was 5.77% and 7.69% respectively，there being no significance in the difference (P＞0.05). Conclusion：Fengliao Changweikang Granules combined with Pivecuronium Bromide Tablets has a significant clinical effect on D- IBS with spleen- stomach damp- heat syndrome， which can help mitigate the clinical symptoms and relieve the inflammatory responses，with good safety.