Abstract： Objective： To observe the clinical effect of extracorporeal shock wave lithotripsy (ESWL) combined with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained- Release Capsules for urinary calculi with damp- heat accumulation syndrome. Methods： A total of 86 cases of patients with urinary calculi with damp- heat accumulation syndrome were selected and divided into the observation group and the control group according to the random number table method，with 43 cases in each group. Both groups were treated with ESWL； after operation， the control group was treated with Tamsulosin Hydrochloride Sustained- Release Capsules， and the observation group was treated with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained-Release Capsules. Both groups were treated for 2 weeks，and follow up for 3 months. The clinical effects，disappearance time of symptoms，recurrence rates and incidence of adverse reactions were compared between the two groups. Results： After treatment，the cure rate was 97.67% in the observation group，higher than that of 83.72% in the control group，the difference being significant (P＜0.05). The stone expulsion time，the disappearance time of low back pain and the disappearance time of gross hematuria in the observation group were shorter than those in the control group (P＜0.05). The incidence of adverse reactions was 2.33% in the observation group and 4.65% in the control group，there being no significance in the difference (P＞0.05). The recurrence rate was 4.76% in the observation group， lower than that of 19.44% in the control group， the difference being significant (P＜0.05). Conclusion： ESWL combined with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained- Release Capsules for urinary calculi with damp- heat accumulation syndrome， which can effectively shorten the stone expulsion time and the disappearance time of symptoms，reduce the recurrence rates and improve the stone expulsion rates，with good safety.