Abstract： Objective： To observe the clinical effect of Gukang Capsules in assisting percutaneous kyphoplasty (PKP) to treat osteoporotic vertebral compression fractures (OVCF) and its influence on bone metabolism. Methods：A total of 78 OVCF patients were randomly divided into the treatment group and the control group，with 39 patients in each group. The control group was treated with PKP，and the treatment group was additionally treated with Gukang Capsules based on the treatment of the control group. The clinical effects and occurrence of adverse reactions between the two groups were compared， and the levels of bone metabolic indexes， including serum osteocalcin (OC)， bone mineral density (BMD) and Ca2+，and inflammatory indexes，including serum nitric oxide (NO)，tumor necrosis factor-α (TNF-α) and interleukin- 6 (IL- 6)， were also compared between the two groups before and after treatment. Results： The total effective rate was 97.44% in the treatment group and 79.49% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference in the levels of OC，Ca2 + and BMD between the two groups (P＞0.05). After treatment， the levels of OC， Ca2 + and BMD in the control group had no significant changes when compared with those before treatment (P＞0.05)；the levels of OC，Ca2 + and BMD in the treatment group were increased when compared with those before treatment (P＜0.05)，and significantly higher than those in the control group (P＜0.05). Before treatment，there was no significant difference in the levels of NO， TNF- α and IL- 6 between the two groups (P＞0.05). After treatment，the levels of NO，TNF-α and IL-6 in both groups were decreased when compared with those before treatment (P＜0.05)，and the levels of NO，TNF-α and IL-6 in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 7.69% in the treatment group and 10.25% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion：The therapy of Gukang Capsules combined with PKP in the treatment of OVCF can significantly improve the clinical effect， promote the increase of bone density， enhance bone metabolism and osteoporosis，and reduce inflammation，with relatively few adverse reactions.