Abstract： Objective： To observe the clinical effect of Yinhua Miyanling Tablets combined with antibiotics for sequelae of pelvic inflammatory disease (PID) with damp- heat stagnation syndrome and its effect on levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in serum. Methods：A total of 64 cases of patients with sequelae of PID were selected and divided into the treatment group and the control group according to the random number table method，with 32 cases in each group. The control group was given routine antimicrobial therapy including Ornidazole Tablets and Levofloxacin Tablets， and the treatment group was additionally treated with Yinhua Miyanling Tablets based on the treatment of the control group. Both groups were treated for 3 menstrual cycles. The blood routine indexes，syndrome scores of dampheat stagnation syndrome， levels of IL- 6 and IL- 8 in serum， and total clinical effects were compared between the two groups. Results：The total effective rate was 96.88% in the treatment group and 75.00% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of white blood cell counts and neutrophil proportion between the two groups (P＞0.05). After treatment， the white blood cell counts and neutrophil proportion in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the two indexes in the treatment group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of traditional Chinese medicine (TCM) syndromes including distending pain in lower abdominal， fixation in pain place， distending pain in lumbosacral spine， large leukorrhea amount， yellow and thick leukorrhea， alternative low- grade fever， mental fatigue and lack of strength，large menstrual volume，brown urine and dry stool between the two groups (P＞0.05). After treatment，the above TCM syndrome scores in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the above TCM syndrome scores in the treatment group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of IL- 6 and IL-8 in serum between the two groups (P＞0.05). After treatment，the levels of IL-6 and IL-8 in serum in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the two indexes in the treatment group were lower than those in the control group (P＜0.05). Conclusion： Yinhua Miyanling Tablets combined with antibiotics for PID with damp- heat stagnation syndrome can further inhibit inflammatory responses and significantly improve TCM syndromes，whose curative effect is better than that of simple antibiotics.