Abstract：Objective：To observe the clinical effect of Bushen Huoxue Decoction on infertility caused by luteal phase defect (LPD). Methods：A total of 78 cases with infertility caused by LPD were selected and divided into the treatment group and the control group by random number table method ， with 40 and 38 cases in each group respectively. The control group was given Progesterone Capsules， and the treatment group was treated with Bushen Huoxue Decoction based on the treatment of the control group. After treatment for 3 menstrual cycles，the clinical effects，traditional Chinese medicine (TCM) syndrome scores，endometrial receptivity and levels of serum estrogen in both groups were compared；the patients were followed up for 6 months and the pregnancy between the two groups were compared. Results：The total effective rate was 87.50% in the treatment group，higher than that of 68.42% in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the TCM scores in the two groups (P＞0.05)；after treatment，the TCM scores in both groups were decreased when compared with those before treatment (P＜0.05)， and the TCM scores in the treatment group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of endometrial thickness，and pulsatility index (PI) and resistance index (RI) of uterine artery between the two groups (P＞0.05). After treatment，the endometrial thickness in both groups was increased when compared with that before treatment (P＜0.05)， and the PI and RI were decreased (P＜0.05)；the endometrial thickness in the treatment group was higher (P＜0.05)， and the levels of PI and RI were lower compared with those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of progesterone (P) and estradiol (E2) between the two groups (P＞0.05)；after treatment，the levels of P and E2 in both groups were significantly increased when compared with those before treatment (P＜0.05)；the above two levels in the treatment group were lower than those in the control group (P ＜ 0.05). After 6 months of follow- up， the conception rate was 42.50% in the treatment group， higher than that of 15.79% in the control group， the difference being significant (P＜0.05). Conclusion： Modified Bushen Huoxue Decoction combined with progesterone for LPD infertility can significantly improve the endometrial receptivity and the clinical symptoms of patients and increase the conception rate， which has a better clinical effect than that of simple western medicine.