Abstract： Objective： To observe the clinical effect of the therapy of Chaichen Zexie Decoction and wrist- ankle acupuncture combined with Betahistine Mesylate Tablets on Meniere's disease of phlegmdamp type. Methods：A total of 60 patients with Meniere's disease of phlegm-damp type were divided into the treatment group and the control group according to the random number table method，with 30 cases in each group. Both groups were given health education and Betahistine Mesylate Tablets. The control group was treated with wrist-ankle acupuncture，and the treatment group was additionally treated with Chaichen Zexie Decoction based on the treatment of the control group. Both groups were treated for 4 weeks. Before and after treatment，the scores of Dizziness Handicap Inventory (DHI)，Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS) for aural fullness and traditional Chinese medicine (TCM) syndrome scores in the two groups were evaluated. The peak systolic velocity in the left and the right vertebral artery in the two groups was also detected. The clinical effects and incidence of adverse reactions were compared between the two groups. Results：After treatment，the total effective rate was 93.33% in the treatment group， higher than that of 73.33% in the control group， the difference being significant (P＜0.05). The scores of DHI，THI，VAS for aural fullness and TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05). The above four scores in the treatment group were lower than those in the control group (P＜0.05). The peak systolic velocity in the left and the right vertebral artery in both groups was faster than those before treatment (P＜0.05). The peak systolic velocity in the left and the right vertebral artery in the treatment group was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Based on the treatment of health education and Betahistine Mesylate Tablets ， the therapy of Chaichen Zexie Decoction combined with wrist-ankle acupuncture can effectively improve the clinical symptoms，such as vertigo，tinnitus and aural fullness，in patients with Meniere's disease of phlegm- damp type and accelerate the blood flow velocity in the vertebral artery，with a definite curative effect，safety and reliability.