Abstract：Objective：To observe the clinical effect of the additional application of retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy for chronic pelvic inflammatory disease (CPID) of qi stagnation and blood stasis type based on the treatment of Ornidazole Sodium Chloride Injection. Methods： A total of 88 cases of CPID patients of qi stagnation and blood stasis type were selected and divided into the control group and the study group according to the random number table method， with 44 cases in each group. The control group was treated with Ornidazole Sodium Chloride Injection，and the study group was additionally treated with retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy based on the treatment of the control group. Both groups were given 2- week treatment and 6- month follow- up. The clinical effects，traditional Chinese medicine syndrome scores，levels of C- reactive protein (CRP) in serum，and the recurrence rates were compared between the two groups. Results：After 1-week and 2-week treatment，the scores of lower abdominal pain，lumbosacral spinal fullness and weakness，abnormal menstruation，and abnormal leukorrhea in the two groups were decreased when compared with those before treatment (P＜0.05)， and the scores of lower abdominal pain，lumbosacral spinal fullness and weakness，abnormal menstruation，and abnormal leukorrhea in the study group were lower than those in the control group at the same period (P＜0.05). The total effective rate of clinical effect was 90.91% in the study group， higher than that of 72.73% in the control group (P＜0.05). After 1-week and 2-week treatment，the CRP levels in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the CRP level in serum in the study group was lower than that in the control group at the same period (P＜0.05). After 6-month followup， there was no recurrence in the study group，and the recurrence rate was 15.63% in the control group， there being significance in the difference (P＜0.05). Conclusion： Based on the treatment of Ornidazole Sodium Chloride Injection， the additional application of retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy has a significant effect in treating CPID of qi stagnation and blood stasis type， which is helpful to relieve clinical symptoms， decrease inflammatory responses and reduce recurrence.