Abstract： Objective： To observe the clinical effect of modified Xiangsha Liujunzi Decoction for hyperemesis gravidarum of spleen- stomach weakness type. Methods： A total of 100 cases of patients with hyperemesis gravidarum of spleen- stomach weakness type were randomly divided into the control group and the observation group，with 50 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with modified Xiangsha Liujunzi Decoction based on the treatment of the control group. Clinical effects and the incidence of adverse reactions were compared between the two groups. The scores of symptoms，sleep situation indexes，and quality of life were compared before and after treatment between the two groups. Results： The total effective rate was 98.00% in the observation group，higher than that of 86.00% in the control group (P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of symptom scores including nausea and vomiting， oppression and distension in the chest and stomach cavity， and mental fatigue and lack of strength between the two groups (P＞0.05)； after treatment， the above symptom scores in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the scores in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of sleep latency，actual sleep duration，and the scores of Pittsburgh Sleep Quality Index (PSQI) between the two groups (P＞0.05). After treatment，the sleep latency in the two groups was shortened (P＜0.05)，actual sleep duration prolonged (P＜0.05)，and PSQI scores decreased (P＜0.05)；the sleep latency in the observation group was shorter than that in the control group (P＜0.05)，the actual sleep duration in the observation group was longer than that in the control group (P＜0.05)，and the PSQI scores in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of World Health Organization Quality of Life Brief Version (WHOQOL-BREF) between the two groups (P＞0.05)；after treatment，each score of WHOQOL-BREF in the two groups was increased when compared with that before treatment (P＜0.05)，and the scores in the observation group were higher than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Modified Xiangsha Liujunzi Decoction has a good curative effect in the treatment of hyperemesis gravidarum of spleenstomach weakness type and the remission of the symptoms，and is conducive to improving the quality of sleep and life of patients，with fewer adverse reactions after treatment and good safety.