Abstract： Objective： To observe the clinical effect of Yinxingye Tablets combined with Ticagrelor on angina pectoris of coronary heart disease and its effects on the heart function and hemorheology. Methods： A total of 90 patients with angina pectoris of coronary heart disease were divided into the control group and the observation group according to the random number table method， with 45 cases in each group. The control group was given Ticagrelor， and the observation group was additionally treated with Yinxinye Tablets based on the treatment of the control group. The two groups were treated for 2 months. The clinical effects， adverse reactions， traditional Chinese medicine (TCM) syndrome scores， incidence of angina pectoris， heart function and hemorheology indexes in the two groups were compared. Results： After treatment， the TCM syndrome scores in the two groups were decreased (P＜0.05)， and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). The total effective rate was 93.33% in the observation group，higher than that of 82.22% in the control group (P＜ 0.05). After treatment，the frequency and duration of angina pectoris attacks in both groups were reduced (P＜0.05)，and the frequency and duration of angina pectoris attacks in the observation group were lower than those in the control group (P＜0.05). After treatment， the left ventricular end- systolic diameter (LVESD) and left ventricular end- diastolic diameter (LVEDD) in both groups were decreased (P＜0.05) and the left ventricular ejection fraction (LVEF) was increased (P＜0.05)， and the LVESD and LVEDD in the observation group were lower than those in the control group (P＜0.05)，and the LVEF was higher than that in the control group (P＜0.05). After treatment， the whole blood contrast viscosity， plasma specific viscosity， blood reduced viscosity and plasma fibrinogen (FIB) in both groups were decreased (P＜0.05)， and the above four hemorheology indexes in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.44% in the observation group，lower than that of 15.55% in the control group (P＜0.05). Conclusion：Yinxingye Tablets combined with Ticagrelor for angina pectoris of coronary heart disease can increase the clinical effect，reduce the adverse reactions as well as the frequency and duration of angina pectoris attacks，and improve the heart function and hemorheology.