Abstract： Objective： To observe the curative effect of Shugan Liqi Huoxue Prescription on patients with endometriosis of qi stagnation and blood stasis type. Methods： A total of 106 patients with endometriosis were selected as the research subjects and randomly divided into the observation group and the control group according to the sealed envelope method，with 53 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally given Shugan Liqi Huoxue Prescription based on the treatment of the control group. The clinical effects in both groups were compared. Before and after treatment，the traditional Chinese medicine (TCM) syndrome scores，and the levels of sex hormones， angiogenic factors and inflammatory factors in the two groups were also compared. Results： The total effective rate was 96.23% in the observation group， higher than that of 84.91% in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of TCM syndrome scores of abdominal pain during menstrual period， menstrual blood with stasis， sore and weak waist and knees， painful sexual intercourse and tender tubercle of sacral ligament between the two groups (P＞0.05)；after treatment，the above five TCM syndrome scores in both groups were decreased (P＜0.05)， and the above five scores in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of luteinizing hormone (LH)，follicle stimulating hormone (FSH) and estradiol (E2) between the two groups (P＞0.05)；after treatment，the levels of LH，FSH and E2 in the two groups were decreased (P＜0.05)， and the above three levels in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of tumor necrosis factor- α (TNF- α)，interleukin- 6 (IL- 6) and interleukin- 8 (IL- 8) between the two groups (P＞0.05)；after treatment，the levels of TNF-α，IL-6 and IL-8 in both groups were decreased，and the above three levels in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of serum carbohydrate antigen 125 (CA125)，angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) between the two groups (P＞0.05)；after treatment，the levels of CA15，Ang-2 and VEGF in both groups were decreased (P＜0.05)， and the above three levels in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of serum matrix metalloproteinase- 9 (MMP- 9)，matrix metalloproteinase- 2 (MMP- 2) and monocyte chemotactic protein- 1 (MCP- 1) between the two groups (P＞0.05)； after treatment，the levels of MMP-9，MMP-2 and MCP-1 in both groups were decreased (P＜0.05)，and the above three levels in the observation group were lower than those in the control group (P＜0.05). Conclusion：Shugan Liqi Huoxue Prescription has a better application effect on patients with endometriosis of qi stagnation and blood stasis type， which can significantly improve the clinical symptoms and TCM syndromes of patients， effectively regulate the levels of sex hormones and angiogenic factors， and mitigate the inflammatory responses of the body.