Abstract：Objective：To observe the effect of modified Bushen Antai Decoction combined with lowdose Aspirin on the coagulation function ， angiogenesis and the expression level of fibroblast growth factor 21 (FGF21) of patients with recurrent abortion (RA). Methods：A total of 82 patients with RA were selected and divided into the control group and the observation group according to the random number table method， with 41 cases in each group. The control group was treated with low- dose aspirin， and the combination group was additionally given modified Bushen Antai Decoction based on the treatment of the control group. Before and after treatment， the traditional Chinese medicine (TCM) syndrome scores， coagulation function，including serum protein S (PS)，protein C (PC)，antithrombin-Ⅲ(AT-Ⅲ)，prothrombin time (PT) and activated partial thromboplastin time (APTT)，angiogenesis indexes，including serum serine/ threonine protein kinase (AKT)， phosphatidylinositol- 3- kinase (PI3K) and endostatin (ES)， and FGF21 in the two groups were compared. The curative effect of TCM syndrome and the success rate of fetal preseration in both groups were evaluated. Results： The total effective rate of TCM syndrome in the combination group was better than that in the control group，and the success rate of fetal preseration in the combination group was higher than that in the control group (P＜0.05). After treatment，the scores of sore and weak waist and knees， bearing- down pain of lower abdomen， dizziness and tinnitus， white complexion and vaginal bleeding as well as the total scores in the two groups were decreased when compared with those before treatment， and the above five scores in the combination group were lower than those in the control group，differences being significant (P＜0.05). After treatment，the contents of serum PS， PC， AT- Ⅲ ， AKT， PI3K and FGF21 in both groups were significantly increased when compared with those before treatment，the PT and APTT were obviously extended，and the ES level was decreased (P＜0.05)；the contents of serum PS，PC，AT-Ⅲ，AKT，PI3K and FGF21 in the combination group were higher than those in the control group，the PT and APTT were longer than those in the control group，and the ES level was lower than that in the control group (P＜0.05). Conclusion：Modified Bushen Antai Decoction combined with low- dose Aspirin for RA can effectively improve the clinical symptoms of patients and hemorheology，promote the angiogenesis of maternal- fetal interface，regulate the vascular endothelial function of placenta tissue，and enhance the effect of fetal protection.