Abstract：Objective：To observe the clinical efficacy of modified Qingre Chushi Liangxue Prescripetion in the auxiliary treatment of facial acne of damp-heat type. Methods：96 patients with facial acne of damp heat type were randomly divided into the treatment group and the control group with 48 cases each. The control group was treated with conventional western medicine，and the treatment group was treated with modified Qingre Chushi Liangxue Prescripetion on the basis of the control group. The traditional Chinese medicine (TCM) syndrome score， skin lesion symptom score and skin physiological indexes (epidermal sebum content， cuticle water content and transcutaneous water loss) were compared between the two groups before and after treatment； the clinical efficacy and relapse of the two groups were evaluated. Results：After treatment，the total effective rate of the treatment group was 93.75%，which was higher than that of the control group (79.17%，P＜0.05). After treatment，the scores of TCM syndromes and skin lesions such as the number，degree，swelling and pain，color of skin lesions in the two groups were lower than those before treatment (P＜0.05)，and the scores of TCM syndromes and skin lesions in the treatment group were lower than those in the control group after treatment (P＜0.05). After treatment，the content of epidermal sebum and the amount of transcutaneous water loss in both groups were lower (P＜0.05)，and the moisture content in the stratum corneum was higher than those before treatment (P＜0.05). The content of epidermal sebum and the amount of transcutaneous water loss in the treatment group were lower than those in the control group (P＜0.05)， and the moisture content in the stratum corneum was higher than that in the control group (P＜0.05). Six-month follow-up showed that the recurrence rate in the treatment group was 4.44% ， which was lower than 21.05% in the control group (P＜0.05). Conclusion： The modified Qingre Chushi Liangxue Prescripetion has a significant effect on the treatment of facial acne of damp-heat type，which can effectively improve the skin lesion symptoms and skin physiological indicators of patients，and reduce the recurrence of the disease.