Abstract： Objective： To observe the clinical effect of Quyu Shupi Decoction combined with routine western medicine for precancerous lesions of chronic atrophic gastritis. Methods：A total of 132 cases of patients with precancerous lesions of chronic atrophic gastritis were selected and divided into the observation group and the control group according to the random number table method，with 66 cases in each group. The control group was given 14- day sequential therapy， and the observation group was additionally treated with Quyu Shupi Decoction based on the treatment of the control group. The clinical effects in the two groups were evaluated； traditional Chinese medicine (TCM) syndrome scores and histopathological scores before and after treatment were compared between the two groups；the levels of nitrite， lactic acid， free acid， total acid and gastrin (GAS) in gastric juice， and trypsinogen 2 (TAT- 2)， pepsinogen (PG) and Golgi protein (GP73) in serum were detected；the medication safety was compared between the two groups. Results：The total effective rate was 78.79% in the observation group，higher than that of 60.61% in the control group，the difference being significant (P＜0.05). After treatment，TCM syndrome scores in the two groups were decreased when compared with those before treatment，and the scores in the observation group were lower than those in the control group，differences being significant (P＜0.05). After treatment，the scores of dysplasia，atrophy，inflammation and intestinal biochemistry in the two groups were decreased when compared with those before treatment， and the scores in the observation group were lower than those in the control group，differences being significant (P＜0.05). After treatment，the levels of GAS，PGⅠand PGⅡ in the two groups were increased when compared with those before treatment，and the levels of TAT-2 and GP73 were decreased；the levels of GAS，PGⅠ and PGⅡ in the observation group were higher that in the control group， and the levels of TAT- 2 and GP73 were lower than that in the control group，differences being significant (P＜0.05). After treatment，the levels of nitrite and lactic acid in the two groups were decreased， and the levels of free acid and total acid were increased；the levels of nitrite and lactic acid in the observation were lower than that in the control group， and the levels of free acid and total acid were higher than that in the control group， differences being significant (P＜0.05). Conclusion： Quyu Shupi Decoction combined with routine western medicine has a significant curative effect in the treatment of precancerous lesions of chronic atrophic gastritis，which can effectively improve the clinical symptoms，gastric pathological conditions，and the pH value of gastric fluid.