Abstract：Objective：To observe the clinical effect of Suzi Jiangqi Decoction combined with western medicine on acute exacerbation of chronic obstructive pulmonary disease and its effects on inflammatory responses. Methods： A total of 88 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into two groups，with 44 cases in each group. The control group was given routine western medicine，and the observation group was additionally treated with Suzi Jiangqi Decoction based on the treatment of the control group. The traditional Chinese medicine(TCM) syndrome scores， including thoracic diaphragm distension and discomfort， expectoration， cough， torpid intake， wheezing and wheezing rales， clinical effects on TCM syndromes， indexes of lung function， including peak expiratory flow (PEF)， forced expiratory volume in one second (FEV1)， forced vital capacity (FVC) and FEV1/FVC， indexes of blood gas analysis， including partial pressure of oxygen in arterial- blood (PaO2)， oxygen saturation (SaO2) and partial pressure of carbon dioxide (PaCO2)， as well as the levels of serum highsensitivity C- reactive protein (hs- CRP)，interleukin- 6 (IL- 6)，procalcitonin (PCT) and D- Dimer (D- D) in both groups were observed. Results： After treatment， the TCM syndrome scores of each item in the observation group were lower than those in the control group，differences being significant (P＜0.05)；the total effective rate of TCM syndromes was 95.45% in the observation group，higher than that of 79.55% in the control group，the difference being significant (P＜0.05). The PEF，FEV1，FVC，FEV1/FVC，PaO2 and SaO2 in the observation group were higher than those in the control group，and the PaCO2 was lower than that in the control group，differences being significant (P＜0.05)；the levels of hs-CRP，IL-6，PCT and D-D in the observation group were lower than those in the control group，differences being significant (P＜ 0.05). Conclusion： Suzi Jiangqi Decoction combined with western medicine for acute exacerbation of chronic obstructive pulmonary disease can mitigate various clinical symptoms，improve the lung function， decrease the levels of inflammatory factors，and enhance the clinical effect.