Abstract：Objective：To observe the clinical effect of Shexiang Tongxin Dripping Pills combined with western medicine for ischemic cardiomyopathy (ICM) complicated with chronic heart failure (CHF) with qi deficiency and blood stasis syndrome. Methods：A total of 100 cases of patients who had ICM complicated with CHF of qi deficiency and blood stasis syndrome were selected and divided into the treatment group and the control group according to the random number table method，with 50 cases in each group. The control group was treated with western medicine，and the treatment group was additionally treated with Shexiang Tongxin Dripping Pills based on the treatment of the control group. Both groups were treated for 4 weeks. Clinical effects were compared between the two groups. Traditional Chinese medicine (TCM) syndrome scores， the heart function indexes [mean wall stress (MWS)， left ventricular myocardial mass index (LVMI)，serum N-terminal B-type natriuretic peptide (NT-proBNP)]，and the levels of serum receptor for advanced glycation end products (RAGE)，nuclear factor- κB (NF- κB)，and S100 calcium-binding protein A8/A9 complex (S100A8/A9) before and after treatment were compared between the two groups. Results： After treatment， the total clinical effective rate was 98.00% in the treatment group， higher than that of 86.00% in the control group (P＜0.05). After treatment， TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the score in the treatment group was lower than that in the control group (P＜0.05). After treatment，the levels of MWS，LVMI，and serum NT- proBNP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of MWS，LVMI，and serum NT-proBNP in the treatment group were lower than those in the control group (P＜0.05). After treatment，the levels of RAGE，NF-κB，and S100A8/A9 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of RAGE， NF-κB，and S100A8/A9 in serum in the treatment group were lower than those in the control group (P＜ 0.05). Conclusion：Shexiang Tongxin Dripping Pills combined with western medicine has a definite curative effect in treating ICM complicated with CHF of qi deficiency and blood stasis syndrome， and can relieve clinical symptoms of patients and improve their heart function. Its mechanism may be related to the downregulation of the levels of serum RAGE，NF-κB，and S100A8/A9.