Abstract： Objective： To observe the clinical effect of Moluo Pills combined with routine western medicine for chronic atrophic gastritis (CAG) and its effects on epidermal growth factors (EGF) and epidermal growth factor receptors (EGFR). Methods：A total of 80 cases of CAG patients were divided into the control group and the treatment group according to the random number table method， with 40 cases in each group. The control group was treated with routine western medicine， and the treatment group was additionally treated with Moluo Pills based on the treatment of the control group. Both groups were treated for three courses，with one month being one course. After treatment，clinical effects，traditional Chinese medicine syndrome scores，levels of EGF in serum，the positive rates of EGFR in gastric mucosa，and the incidence of adverse reactions were evaluated. Results：The total clinical effective rate was 92.50% in the treatment group， better than that of 70.00% in the control group， the difference being significant (P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of scores of distention and fullness in the gastric cavity，pain in the gastric cavity，distending pain in the chest and ribside， poor appetite，and dryness and bitter taste in the mouth between the two groups (P＞0.05)；after treatment， the above syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and each score in the treatment group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of serum EGF levels between the two groups (P＞0.05)； after treatment， EGF levels in the two groups were decreased when compared with those before treatment (P＜0.05)， and the level in the treatment group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the positive rates of EGFR in gastric mucosa between the two groups (P＞ 0.05)； after treatment， the positive rates of EGFR in gastric mucosa in the two groups were decreased when compared with those before treatment (P＜0.05)，and the positive rate of EGFR in gastric mucosa in the treatment group was lower than that in the control group (P＜0.05). The total incidence of adverse reactions was 7.50% in the treatment group and 10.00% in the control group，there being no significance in the difference (P＞0.05). Conclusion：Moluo Pills combined with routine western medicine has significant curative effects in the treatment of CAG，and can effectively relieve clinical symptoms，reduce the levels of serum EGF and the expression of EGFR in gastric mucosa with good medication safty.