Abstract：Objective：To observe the clinical effect of the therapy of Yangwei Granules combined with Rabeprazole Sodium Enteric- Coated Tablets on chronic gastritis complicated with reflux esophagitis of spleen deficiency and qi stagnation syndrome. Methods： A total of 86 patients with chronic gastritis complicated with reflux esophagitis of spleen deficiency and qi stagnation syndrome were selected and divided into the treatment group and the control group by simple randomized method， with 43 cases in each group. Both groups were given dietary guidance. On this basis， the control group was additionally treated with Rabeprazole Sodium Enteric-Coated Tablets，and the treatment group was additionally treated with Yangwei Granules based on the treatment of the control group. Both groups were treated for 2 weeks. The clinical effects，incidence of adverse reactions and the traditional Chinese medicine (TCM) syndrome scores， gastrointestinal hormone levels and inflammatory factors levels before and after treatment were compared between the two groups. Results：After treatment，the total effective rate was 95.35% in the treatment group，higher than that of 81.40% in the control group (P＜0.05). After treatment，the scores of epigastric distension pain or fullness，acid reflux，heartburn，mental fatigue and lack of strength，sallowyellow complexion and loss of appetite in the two groups were all decreased when compared with those before treatment (P＜0.05)，and the above 6 TCM syndrome scores in the treatment group were lower than those in the control group (P＜0.05). After treatment，the levels of plasma motilin (MLT) and serum gastrin (GAS) in the two groups were increased when compared with those before treatment (P＜0.05)， and the levels of serum interleukin-6 (IL-6) and interleukin-17 (IL-17) were decreased when compared with those before treatment (P＜0.05)；the levels of plasma MLT and serum GAS in the treatment group were higher than those in the control group (P＜0.05)，and the levels of serum IL-6 and IL-17 were lower than those in the control group (P＜0.05). During the treatment， the incidence of adverse reactions was 4.65% in the treatment group and 9.30% in the control group， there being no significant difference between the two groups (P>0.05). Conclusion： The therapy of Yangwei Granules combined with Rabeprazole Sodium Enteric- Coated Tablets has a definite therapeutic effect on the treatment of chronic gastritis complicated with reflux esophagitis of spleen deficiency and qi stagnation syndrome，which can effectively relieve the clinical symptoms of patients，improve gastric motility，inhibit inflammatory responses，with good safety.