Abstract：Objective：To observe the effect of Houpo Paiqi Mixture combined with Methylprednisolone for early postoperative inflammatory small bowel obstruction (EPISBO) of colorectal cancer based on routine therapy. Methods： A total of 168 cases of patients with EPISBO of qi stagnation type after laparoscopic resection of colorectal cancer were randomly divided into the control group and the observation group，with 84 cases in each group. Both groups were given routine therapies including the correction of water and electrolyte disturbances； the control group was treated with Methylprednisolone Sodium Succinate of Injection， and the observation group was treated with Houpo Paiqi Mixture combined with Methylprednisolone Sodium Succinate of Injection. Both groups were continuously treated for 6 days. Serum neuroinflammatory mechanism- related indicators [somatostatin (SS)， vasoactive intestinal peptide (VIP)， nitric oxide (NO)，monocyte chemoattractant protein- 1 (MCP-1)，hypersensitive C-reactive protein (hs- CRP)] and fecal biomarkers [calprotectin (FC)， lactoferrin (LF)] were detected before and after treatment. The recovery of gastrointestinal function in the two groups was observed， and clinical effects were evaluated. Results：After treatment，the total effective rate in the observation group was higher than that in the control group，and the overall curative effect was better than that in the control group，differences being significant (P＜0.05). The remission time of abdominal pain and abdominal distention in the observation group were shorter than those in the control group， the recovery time of bowel sound， the first ventilation time and the first defecation time were earlier than those in the control group (P＜0.05). The levels of SS in serum in the two groups were increased when compared with those before treatment (P＜ 0.05)， and the SS level in the observation group was higher than that in the control group (P＜0.05)；the levels of VIP，NO，MCP-1 and hs-CRP in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above 4 indexes in the observation group were lower than those in the control group (P＜0.05). The levels of FC and LF in faeces in the two groups were decreased when compared with those before treatment (P＜0.05)，and the 2 indexes in the observation group were lower than those in the control group (P＜0.05) Conclusion： Based on routine therapy， Houpo Paiqi Mixture combined with Methylprednisolone has significant clinical effects in treating EPISBO of qi stagnation type after the surgery of colorectal cancer， and can effectively correct gastrointestinal neurohormonal disorders，reduce inflammatory reactions，and promote gastrointestinal function recovery.