Abstract：Objective：To observe the effect of Yiqi Sanjie Prescription combined with routine therapy on patients after surgery of colorectal adenomas. Methods： A total of 109 cases of patients who had the syndrome of damp- heat due to spleen deficiency and blood stasis and received endoscopic resection of colorectal adenoma were selected as the study objects， and were divided into the control group and the observation group according to the random number table method， with 54 and 55 cases in each group respectively. Both groups were treated with routine therapies such as postoperative hemostasis， antiinfection， and nutritional support for 8 weeks， and the observation group was additionally given the oral administration with Yiqi Sanjie Prescription for 8 weeks. Before treatment and after 8 weeks of treatment， the clinical symptom scores were evaluated，the cytokines including interleukin- 6 (IL-6)，tumor necrosis factor- α (TNF- α)，and C- reactive protein (CRP)，and tumor markers including carcinoembryonic antigen (CEA)，carbohydrate antigen 199 (Ca199) and carbohydrate antigen 50 (Ca50) were detected. The incidence of adverse reactions during treatment was recorded in the two groups. After 8 weeks of treatment， the clinical effects were evaluated. The recurrence of adenoma at 3 and 6 months after the surgery，and the growth of adenoma during the first 6 months after the surgery were rechecked and counted. Results：After 8 weeks of treatment，the clinical effect in the observation group was better than that in the control group (P＜0.05). The levels of TNF- α，CRP，CEA，Ca199，and Ca50 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the 6 indexes in the observation group were lower than those in the control group (P＜0.05). The scores of abdominal pain，stool characteristics，defecation frequency， and stool with mucus in the two groups were decreased when compared with those before treatment (P＜0.05)，and the 4 scores in the observation group were lower than those in the control group (P＜0.05). There was no serious adverse reaction in the two groups during treatment. The recurrence rates of adenoma in the observation group at 3 months and 6 months after the surgery were lower than those in the control group (P＜0.05). The number of adenomas in the observation group was less than that in the control group 6 months after the surgery，and the maximum diameter and average diameter of adenomas in the observation group were smaller than those in the control group， differences being significant (P＜ 0.05). Conclusion：For patients who had the syndrome of damp- heat due to spleen deficiency and blood stasis and received endoscopic resection of colorectal adenoma，Yiqi Sanjie Prescription based on routine therapy has a significant effect，and can effectively relieve inflammatory responses，inhibit the proliferation and metastasis of tumor cells， improve clinical symptoms， and reduce the recurrence rate of adenoma， with high safety.