Abstract： Objective： To observe the clinical effect of Shaoshanhuo needling method combined with Clostridum Butyricum Capsules on chronic diarrhea with cold-damp syndrome. Methods：A total of 98 patients with chronic diarrhea with cold- damp syndrome were selected and divided into the control group and the observation group according to the random number table method，with 49 cases in each group. The control group was treated with Clostridum Butyricum Capsules，and the observation group was additionally given Shaoshanhuo needling method based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects， and the defection times， the scores of stool form and levels of nutritional indexes including hemoglobin (Hb)，albumin (Alb) and total protein (TP) before and after treatment as well as the incidence of adverse reactions during treatment were compared between the two groups. Results： After treatment，the total clinical effective rate was 91.84% in the observation group，higher than that of 75.51% in the control group (P＜0.05). After treatment，the defecation times in both groups were reduced when compared with those before treatment (P＜0.05)，and the scores of Bristol Stool Form Scale (BSFS) were decreased when compared with those before treatment (P＜0.05)； the defecation time in the observation group was less than that in the control group (P＜0.05)，and the BSFS score was lower than that in the control group (P＜0.05). After treatment，the levels of serum Hb，Alb and TP in the two groups were increased when compared with those before treatment (P＜0.05)， and the above 3 levels in the observation group were higher than those in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 8.16% in the observation group and 4.08% in the control group， there being no significance in the difference (P＞0.05). Conclusion： Shaoshanhuo needling method combined with Clostridum Butyricum Capsules has a definite effect on chronic diarrhea with cold-damp syndrome，which can promote the mitigation of symptoms and improve the nutritional status of patients，with good safety.