Abstract：Objective：To observe the clinical effect of point application with Chinese herbal medicine for senile insomnia with coexistence of multiple diseases of different syndrome types of Chinese medicine. Methods：Sixty cases of senile insomnia patients with coexistence of multiple diseases of liver constraint transforming into fire type， phlegm- heat harassing the interior type， yin deficiency resulting in vigorous fire type， deficiency of both the heart and spleen type， and heart deficiency with timidity type were respectively included， and each type was randomly divided into the control group and the observation group， with 30 cases in each group of each type respectively. Both groups were given routine western medicine treatment，life habits and psychological guidance for their basic diseases. The control group was treated with Estazolam Tablets，and the observation group was treated with point application with Chinese herbal medicine. The recent clinical effects， scores of Pittsburgh Sleep Quality Index (PSQI) and Fatigue Scale- 14 (FS- 14)， and adverse drug reactions were observed in the two groups. Results： The total effective rate of clinical effect was 64.00% in the observation group and 30.00% in the control group，the difference being significant (P＜0.05). Compared with those in the control groups of different syndrome types，there were significant differences being found in the comparison of sleep effects in the observation groups of liver constraint transforming into fire type， phlegm- heat harassing the interior type， and yin deficiency resulting in vigorous fire type (P＜0.05). The scores of time before falling asleep， sleep disorders， daytime function in the observation groups were lower than those in the control groups (P＜ 0.05)； the PSQI scores in the observation groups of liver constraint transforming into fire type， yin deficiency resulting in vigorous fire type， and phlegm- heat harassing the interior type were lower than those in the control groups (P＜0.05)；the scores of time before falling asleep in the observation groups of different syndrome types were lower than those in the control groups (P＜0.05)； the scores of sleep disorders in the observation groups of the other syndrome types except deficiency of both the heart and spleen type were lower than those in the control groups (P＜0.05)； the scores of sleep quality in the observation groups of liver constraint transforming into fire type and phlegm-heat harassing the interior type were lower than those in the control groups (P＜0.05)；the scores of daytime function in the observation groups of phlegm- heat harassing the interior type and yin deficiency resulting in vigorous fire type were lower than those in the control groups (P＜0.05). The FS- 14 scores in the observation groups of liver constraint transforming into fire type，phlegm-heat harassing the interior type，and heart deficiency with timidity type were lower than those in the control groups， differences being significant (P＜0.05). There was no related adverse reactions being found in the two groups during treatment. Conclusion： Point application with Chinese herbal medicine has a significant curative effect in treating senile insomnia with coexistence of multiple diseases，especially for those with elderly insomnia population with the syndrome characteristics of yang hyperactivity and phlegm- heat，which can shorten the time before falling asleep， and reduce the occurrence of sleep disorders，with few adverse reactions.