Abstract：The paper introduces the clinical experience of chief medical practitioner WANG Hongxian in treating insomnia with Chaigui Decoction. WANG holds that the pathogenesis of insomnia lies in yin- yang disharmony，imbalance of qi and blood，and comorbidity of mind and body. The concept of “harmony” should be the foundation of treatment， combined with Chaigui Decoction based on syndrome differentiation. In categories of Chaigui Decoction， Xiaochaihu Decoction is used to move the core， promote qi movement，unblock the inside and outside，harmonize triple energizers，and reach the exterior and interior； Danggui Shaoyao Powder can nourish and invigorate blood， and fortify the spleen to move water and drain dampness. In this way，the combination of harmonizing method and Chaigui Decoction can bring out the best in each other，which can clear the middle energizer，clean the qi and blood，interact and harmonize yin and yang，and finally cure insomnia.