Abstract：This paper introduces the clinical experience of Professor ZHUO Liyong applying the method of regulating the center in treating internal damage and miscellaneous disease. Professor ZHUO attaches great importance to the care of the spleen and stomach in clinical practice. On the basis of Huang Di Nei Jing (The Yellow Emperor's Inner Classic)，Shang Han Za Bing Lun (Treatise on Cold Damage and Miscellaneous Diseases)， and the Earth School founded by LI Dongyuan， Professor ZHUO proposes a thought， the internal circulation of the deficiency and excess qi-transformation of the spleen and stomach which is based on “yang is often in excess，while yin in deficiency” with the spleen and stomach as the core；he also suggests to use the method of regulating middle energizer to treat miscellaneous diseases in the five viscera. In clinical practice，it is found that patients with the kidney damage should supplement essence； those with the heart damage should harmonize the nutrient and defense； patients with the liver damage should revive the middle energizer； those who have the lung damage should boost qi； patients with tumors should pay attention to the spleen and stomach.