Abstract： Objective： To observe the clinical effect of Weijing Decoction combined with western medicine on persistent bacterial bronchitis (PBB) in children. Methods：A total of 85 children with PBB were selected as the study objects，and divided into the control group and the observation group according to the random number table method ， with 42 and 43 cases in each group respectively. The control group was given routine western medicine， and the observation group was treated with oral administration of Weijing Decoction based on the treatment of the control group. The changes of clinical effects，traditional Chinese medicine (TCM) syndrome scores，lung function，inflammatory factors and T lymphocyte subsets were compared between the two groups. Results：The total effective rate was 90.70% in the observation group，higher than that of 73.81% in the control group (P＜0.05). After treatment，the scores of cough and excessive phlegm， coughing of yellow and thick phlegm， and red tongue and yellow coating in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the forced vital capacity (FVC)， forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) in both groups were increased when compared with those before treatment (P＜ 0.05)，and the FVC，FEV1 and PEF in the observation group were higher than those in the control group (P＜ 0.05). After treatment，the levels of interleukin-6 (IL-6)，interleukin-4 (IL-4) and C-reactive protein (CRP) in both groups were decreased when compared with those before treatment (P＜0.05)， and the above three levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of CD3 + and CD4 + in the two groups were increased when compared with those before treatment， and the levels of CD8 + were decreased (P＜0.05)； the levels of CD3 + and CD4 + in the observation group were higher than those in the control group，and the CD8+ level was lower than that in the control group (P＜0.05). Conclusion：Weijing Decoction combined with western medicine has a sound clinical effect on PBB in children， which can significantly improve the clinical symptoms of children， enhance the pulmonary ventilation function， mitigate the inflammatory responses and increase the immunity.