Abstract： Objective： To observe the clinical effect of modified Taohong Siwu Decoction on patients who had undergone the open reduction and internal fixation after tibial plateau fracture of qi stagnation and blood stasis type. Methods： A total of 118 patients who had undergone the open reduction and internal fixation after tibial plateau fracture of qi stagnation and blood stasis type were randomly divided into the control group and the observation group， with 59 cases in each group. The control group was given conventional treatment， and the observation group was additionally treated with an oral administration of modified Taohong Siwu Decoction based on the treatment of the control group. After 12 weeks of treatment，the clinical effects in the two groups were compared. Results：The total excellent-and-good rate in the observation group was 96.61% ， higher than that of 79.66% in the control group (P＜0.05). Before treatment， there was no significant difference in the levels of serum interleukin- 17 (IL- 17) and tumor necrosis factor-α (TNF-α) between the two groups (P＞0.05). After treatment，the levels of serum IL- 17 and TNF- α in the two groups were decreased (P＜0.05)， and the above levels in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference in the levels of serum cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) between the two groups (P＞0.05). After treatment，the serum COX- 2 and PGE2 levels in the two groups were decreased (P＜0.05)，and the above levels in the observation group were lower than those in the control group (P＜ 0.05). Before treatment， there was no significant difference in the levels of serum alkaline phosphatase (ALP)，osteoprotegerin (OPG) and N- MID osteocalcin (N- MID) between the two groups (P＞0.05). After treatment，the levels of serum ALP，OPG and N- MID in the two groups were increased (P＜0.05)，and the above levels in the observation group were higher than those in the control group (P＜0.05). Before treatment，there was no significant difference in the scores of Hospital for Special Surgery (HSS)，36-item Short- Form Health Survey (SF- 36) and Visual Analogue Scale (VAS) between the two groups (P＞0.05). After treatment， the HSS and SF- 36 scores in the two groups were increased (P＜0.05)， and the VAS scores were decreased (P＜0.05)；the HSS and SF- 36 scores in the observation group were higher than those in the control group (P＜0.05)，and the VAS score in the observation group was lower than that in the control group (P＜0.05). Conclusion： The application of modified Taohong Siwu Decoction in treating patients who had undergone the open reduction and internal fixation after tibial plateau fracture of qi stagnation and blood stasis type， which is helpful to reduce inflammatory responses， regulate bone metabolism indexes，promote functional recovery of knee joint and improve clinical effect.