Abstract： Objective： To observe the clinical effect of Xuanfei Buyi Decoction combined with Glutathione for chronic obstructive pulmonary disease (COPD). Methods： A total of 100 cases of COPD patients were divided into the control group and the study group according to the odd- even number method，with 50 cases in each group. The control group was treated with routine treatment，and the study group was additionally treated with Xuanfei Buyi Decoction combined with Glutathione based on the treatment of the control group. The changes in respiratory function indexes， inflammatory factor levels， and 6- minute walking test (6MWT) before and after treatment， as well as the clinical effects and the incidence of adverse reactions，were compared between the two groups. Results：After treatment，the total effective rate was 98.00% in the study group，higher than that of 70.00% in the control group (P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of the levels of tumor necrosis factor-α (TNF-α)，interleukin-6 (IL-6)，and interleukin-8 (IL-8) between the two groups (P＞0.05). After treatment，the levels of TNF-α，IL-6，and IL-8 in the two groups were decreased when compared with those before treatment，and the three levels in the study group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the forced expiratory volume in one second predicted (FEV1%) and FEV1/forced vital capacity (FVC) between the two groups (P＞0.05). After treatment，FEV1% and FEV1/FVC in the two groups were increased when compared with those before treatment (P＜0.05)，and the two indexes in the study group were higher than those in the control group (P＜0.05). Before treatment， no significant difference was found in the comparison of the 6MWT distance between the two groups (P＞0.05). After treatment， the 6MWT distance in the two groups was prolonged when compared with that before treatment (P＜0.05)， and the distance in the study group was longer than that in the control group (P＜0.05). The total incidence of adverse reactions was 32.00% in the study group，lower than that of 56.00% in the control group (P＜ 0.05). Conclusion： Xuanfei Buyi Decoction combined with Glutathione for COPD can promote the stable recovery of the blood gas and the recovery of respiratory function of patients， and help overcome the oxidative stress reactions caused by the disease，with good safety.