Abstract： Objective： To observe the clinical effect of Biyuan Tongqiao Granules combined with Mometasone Furoate Nasal Spray for allergic rhinitis. Methods：A total of 80 cases of patients with allergic rhinitis were selected and divided into the control group and the observation group according to the random number table method， with 40 cases in each group. The control group was treated with Mometasone Furoate Nasal Spray， and the observation group was additionally treated with Biyuan Tongqiao Granules based on the treatment of the control group. The changes in scores of clinical symptoms， levels of interferon- γ (IFN- γ) and interleukin- 4 (IL- 4) in serum， and scores of Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were compared between the two groups before and after treatment. Results：After treatment，the scores of symptoms including sneezing，nasal congestion，nasal itching and runny nose in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of serum IL-4 in the two groups were decreased when compared with those before treatment，and the levels of serum IFN-γ were increased when compared with those before treatment (P＜0.05)；the level of serum IL- 4 in the observation group was lower than that in the control group，and the level of serum IFN-γ was higher than that in the control group (P＜0.05). After treatment，RQLQ scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and RQLQ score in the observation group was lower than that in the control group (P＜0.05). Conclusion： Biyuan Tongqiao Granules combined with Mometasone Furoate Nasal Spray for allergic rhinitis can effectively regulate the levels of serum inflammatory factors，promote the relief of clinical symptoms，and improve the quality of life of patients.