Abstract：Objective：Through data mining analysis of the treatment of multiple myeloma (MM) cases by contemporary famous doctors， the application of the method of promoting blood circulation and removing blood stasis in MM was explained by the "blood syndromes are mostly associated with blood stasis" in the theory of "thirteen pathogenesis of disease" by traditional Chinese medicine (TCM) master ZHOU Zhongying. Methods：The medical records of contemporary famous doctors in the treatment of MM from the establishment of the database to June 20， 2022 in China National Knowledge Internet (CNKI)， Wanfang Academic Journal Full- text Database (Wanfang)， VIP Chinese Science and Technology Journal Database (VIP) were retrieved. The Medcase data processing platform was used for frequency analysis and association rule analysis. Results：The frequent pathogenesis of MM was blood stasis，qi deficiency and kidney deficiency. The frequent clinical symptoms were fatigue， low back pain and limb numbness and pain. Association analysis showed that limb numbness and pain were highly correlated with blood stasis， and blood stasis was associated with scolopendra and scorpio，etc. Conclusion：Blood stasis is the core pathogenesis of MM. Applying the theory of "blood syndromes are mostly associated with blood stasis" is of great significance to TCM differentiation and treatment strategy of MM in the era of new drugs.