基于数据挖掘研究前庭性偏头痛用药规律
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R747.2

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上海市中医诊疗模式创新试点建设项目2018-10 (ZY〔2018-2020〕-FWTX-6013);上海市虹口区“国医强优”三年行动计划(HGY-YSZK- )


Study on Medication Rules of Chinese Medicinals for Vestibular Migraine Based on Data Mining
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    摘要:

    目的:基于数据挖掘研究中药治疗前庭性偏头痛的用药规律。方法:通过检索中文期刊全文数据 库、中国生物医学文献数据库、维普期刊数据库及万方数据库自建库至2022 年3 月收录的中药治疗前庭性偏 头痛的临床文献,建立数据库并运用数据挖掘技术对中药处方进行描述性分析、关联规则及聚类分析。结果: 共纳入77 篇文献,120 首中药处方,涉及中药86 味,总用药频数1 108 次,使用频率>5%的有5 类,由高到 低分别为补虚药、活血化瘀药、平肝熄风药、解表药、清热药,累计频率79.25%;单药频次>20 的中药有 23 味,累计频率66.06%,分别为川芎、天麻、白芷、茯苓、栀子、甘草、半夏、白术、丹参、黄芩、柴胡、 钩藤、大枣、当归、石菖蒲、陈皮、牛膝、石决明、红花、党参、桃仁、蔓荆子及赤芍;按药性分析,温、 寒、平性药较多,甘、苦、辛味药多见,归经多入肝经、心经、肺经、脾经及胃经;关联规则分析显示白芷- 川芎是支持度最高的药对。通过对频数≥20 的药物进行聚类分析,可将药物分为4 大类,主要涉及通窍活血 汤、天麻钩藤饮、半夏白术天麻汤及八珍汤。结论:中药治疗前庭性偏头痛多以活血化瘀、熄风止痉为主,并 注重补虚,多以通窍活血汤、天麻钩藤饮、半夏白术天麻汤及八珍汤化裁。

    Abstract:

    Abstract:Objective:To study the medication rules of Chinese medicinals for vestibular migraine based on data mining. Methods:Clinical literature of Chinese medicinals for vestibular migraine included from the date when the databases were established to March 2022 was searched from China Journal Full- text Database,China Biomedicial Literature Database (CBM),China Science and Technology Journal Database and Wangfang Database and used to establish a database. Descriptive analysis, association rule analysis and cluster analysis were conducted on the Chinese medicine prescriptions. Results: A total of 77 documents and 120 Chinese medicine prescriptions were included, with 86 Chinese medicinals involved and a total usage frequency up to 1 108 times. Among them,there are 5 types of Chinese medicinals used with a frequency of more than 5%,including deficiency- supplementing medicine,blood- activating and stasis- resolving medicine,liver- calming and wind- extinguishing medicine,exterior- releasing medicine and heat-clearing medicine in descending order,with a totally frequency of 79.25%;there are 23 single Chinese medicinals used for more than 20 times with a totally frequency of 66.06%,including Chuanxiong Rhizoma,Gastrodiae Rhizoma,Angelicae Dahuricae Radix,Poria,Gardeniae Fructus,Glycyrrhizae Radix et Rhizoma, Pinelliae Rhizoma, Atractylodis Macrocephalae Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma,Scutellariae Radix,Bupleuri Radix,Uncariae Ramulus Cum Uncis,Jujubae Fructus,Angelicae Sinensis Radix, Acori Tatarinowii Rhizoma, Citri Reticulatae Pericarpium, Achyranthis Bidentatae Radix, Haliotidis Concha,Carthami Flos,Codonopsis Radix,Persicae Semen,Viticis Fructus and Paeoniae Radix Rubra;in terms of the nature,the Chinese medicinals with warm,cold and mild nature account the most and they are mainly sweet,bitter and acrid in taste. The major meridian entries were the liver meridian,the heart meridian, the lung meridian, the spleen meridian and the stomach meridian; based on the association rule analysis, the couplet medicine with the highest support degree is Angelicae Dahuricae Radix- Chuanxiong Rhizoma. After the cluster analysis on the Chinese medicinals used for over 20 times, the medicinals can be divided into 4 types, mainly involving Tongqiao Huoxue Decoction, Tianma Gouteng Decoction,Banxia Baizhu Tianma Decoction and Bazhen Decoction. Conclusion:Chinese medicinals for vestibular migraine is mainly to invigorate blood and resolve stasis,and extinguish wind and suppress spasm, combined with the supplement of deficiency, and usually with Tongqiao Huoxue Decoction, Tianma Gouteng Decoction, Banxia Baizhu Tianma Decoction and Bazhen Decoction as the prescriptions.

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陆颖,王长德.基于数据挖掘研究前庭性偏头痛用药规律[J].新中医,2023,55(8):13-18

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  • 在线发布日期: 2023-04-25
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