Abstract： Objective： To observe the clinical effect of Yangxue Qingnao Pills for early Parkinson Disease and its effect on cognitive function. Methods： A total of 76 cases of patients with Parkinson Disease were divided into the two groups according to the randomized principle， with 38 cases in each group. The control group was treated with levodopa， and the observation group was additionally treated with Yangxue Qingnao Pills based on the treatment of the control group. Both groups were treated for 12 weeks. Before and after treatment，the changes in cognitive function were compared between the two groups，the frontal executive function were tested and recorded in the two groups；the activities of daily living were observed in the two groups. During treatment，the adverse reactions and clinical effects were compared in the two groups. Results： After treatment， the scores of MMSE， MoCA and BI in the two groups were increased when compared with those before treatment， and the scores of MMSE， MoCA and BI in the observation group were increased when compared with those in the control group， differences being significant (P＜0.05). The results of Verbal Fluency Test in the two groups were increased when compared with those before treatment，and the results of Trail Making Test were shortened when compared with those before treatment； the result of Verbal Fluency Test in the observation group was increased when compared with that in the control group，and the result of Trail Making Test was shortened when compared with that in the control group， differences being significant (P＜0.05). There was no significant difference being found in the comparison of the symptoms of adverse reactions and the total incidence of adverse reactions (P＞0.05). The total clinical effective rate was 94.74% in the observation group and 76.32% in the control group， the difference being significant (P＜0.05). Conclusion： The combination treatment of Yangxue Qingnao Pills for patients with early Parkinson Disease can effectively alleviate the decline of cognitive function， improve the abilities of daily living of patients， and have good safety.